Project open for codevelopment


Therapeutic area: CNS, Psychiatric Disorders

Disease: Schizophrenia

Monogenic inroad: DISC1

Cellular Model: Patient derived glutamatergic neurons

Project Origin: ZI Mannheim, Prof. Andreas Meyer-Lindenberg

Medical need: Schizophrenia is a chronic and severe mental disorder affecting 20 million people worldwide. Schizophrenia is characterized by distortions in thinking, perception, emotions, language, sense of self and behaviour. Common experiences include hallucinations (hearing voices or seeing things that are not there) and delusions (fixed, false beliefs). Worldwide, schizophrenia is associated with considerable disability and may affect educational and occupational performance. Available medications for schizophrenia can cause serious side effects which is the major reason why many patients are reluctant to take them

Goal: The project aims for the development and implementation of a phenotypic approach exploiting a physiologically highly-relevant iPSC-based cellular disease model for screening purposes with the opportunity to deliver lead chemical matter or identify new molecular targets for the development of disease modifying treatments of schizophrenia.

Development stage: Assay validation

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